British Air Force Typhoon jets have joined forces with French aircraft in a combined operation against an hidden munitions depot in Syria operated by the IS group, according to the British defence ministry.
The facility, located using reconnaissance, was assessed as storing arms and explosives, the announcement noted, and was situated in hills just north of the ancient city of Palmyra in the heart of Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to target a series of entry passages providing entry to the depot... initial indications suggest the target was engaged successfully," the MoD said.
There was no indication of any civilian casualties in the attack late on Saturday and all the aircraft returned to base without incident, the MoD added.
The Typhoon FGR4s were supported by a Voyager tanker plane.
IS - also known as Daesh - established jihadist rule over large swathes of Syria and Iraq before its territorial defeat in 2019.
"This strike shows our UK leadership, and resolve to operate in unison with our allies, to stamp out any re-emergence of the terrorist group and their dangerous and violent ideologies in the area," UK Defence Secretary the Defence Secretary said.
British military aircraft have conducted patrols over Syrian airspace to "prevent any attempted comeback" of Islamic State subsequent to its defeat at the climactic battle in Baghuz in the year 2019, the authorities noted.
"I want to thank all the members of British forces participating in this strike for their expertise and their courage," he added. "Including them were thousands of British troops on duty over the festive period. This action, to remove militants who endanger our safety, highlights how British military are prepared to act, throughout the year, ensuring Britain's security domestically and powerful internationally."
Last December, the United States armed forces executed what it called a "major assault" targeting IS targets in Syria, following an attack claimed the lives of two US servicemembers and a local interpreter in Palmyra.
The UN says Islamic State still has between 5,000 and 7,000 militants in both countries.